Hi, I have flexible a flexible loop in my structure and every
time i refine it derange ramachandrans. Can anyone suggest how
can i fix these flexible residues in phenix refinement so
basically i don't wanna refine them. Can i do this in GUI?
Refinement settings -> Modify selections for (XYZ coordinates,
this is the default) -> Edit
then enter atom selections, (example: chain A and resseq 12:15)
Alternatively you can apply Ramachandran plot restraints selectively
to these loops.
Also, doing weights optimization may be helpful too.