Diego



On Fri, Mar 7, 2025 at 12:50 AM DIEGO ORTIZ DE ELGUEA LOPEZ DE DICASTILLO <diego.ortizdeelguea@cib.csic.es> wrote:
Dear phenixbb:

I'm working with a GTP binding protein and have had some problems 
running phenix_refine.

In my unit cell there are two molecules one with GDP and one with GTP, 
which I added in Coot(0.9.8). When refining the following error 
message pops-up : "Fatal problems interpreting model file: Number of 
atoms with unknown nonbonded energy type symbols:4 Please edit  the 
model file to resolve the problems and/or supply a CIF file with 
matching restraint definitions, along with apply_cif_modifications and 
apply_cif_link parameter definitions if necessary". Checking the log 
file I found that the problem seems to be hydrogen atoms from these 
ligands

  Number of atoms with unknown nonbonded energy type symbols: 4
     "HETATM 6499  H5' GTP A 501 .*.     H  "
     "HETATM 6502 H5'' GTP A 501 .*.     H  "
     "HETATM12939  H5' GDP B 501 .*.     H  "
     "HETATM12940 H5'' GDP B 501 .*.     H  "

This is because the restraints in Phenix have the v2 names while your model has v3 names.
 

Including the corresponding .CIF files (dowloaded from PDB) did not 
solve the problem and the same error popped.

The file you downloaded is an information file, not restraints. I have generated restraints using eLBOW (attached).

Nigel
 

Since I'm in the initial stages of the refinement I'm running phenix 
with bindividuals.

Could anybody save my day giving me some light into this issue?

Cheers,

Diego

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