Try seeding so that you get 1000 crystals per drop for example.
You know it's a pain to mount .5 micron crystals or do you want to suck them into a capillary ?
You could also grind your big crystals and see if they still diffract.

Jürgen

On Jul 4, 2012, at 7:55 PM, jens j birktoft wrote:

Hi everybody,

Any suggestions regarding how to generate small!! crystals?  Yes, in this case that is what we want While we can generate crystals of size 100-500 microns, this time we something in the range of .5-5 microns.  Any ideas and suggestions would be greatly appreciated,

Cheers

Jens

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Jürgen Bosch
Johns Hopkins University
Bloomberg School of Public Health
Department of Biochemistry & Molecular Biology
Johns Hopkins Malaria Research Institute
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